Blistering skin diseases: a bridge between dermatopathology and molecular biology
نویسندگان
چکیده
منابع مشابه
Clinicopathological correlation of blistering diseases of skin.
Blistering diseases are alarming skin conditions where blister formation occurs in various ways and cannot be differentiated clinically. For confirmation of diagnosis, along with routine histological examination, immunofluorescence study is essential. Tzanck smear may be used as a rapid diagnostic tool. We included here 34 cases of different blistering lesions. Other than routine Hematoxylin an...
متن کاملMolecular Diagnosis in Autoimmune Skin Blistering Conditions
Blister formation in skin and mucous membranes results from a loss of cell-cell or cell-matrix adhesion and is a common outcome of pathological events in a variety of conditions, including autoimmune and genetic diseases, viral and bacterial infections, or injury by physical and chemical factors. Autoantibodies against structural components maintaining cell-cell and cell-matrix adhesion induce ...
متن کاملEvaluation of serum Prolactin levels in patients with autoimmune blistering skin diseases: A case-control study
Background: Prolactin, a neurohormone, can act as a stimulator of immunity in a number of autoimmune diseases and its high levels have been shown in these diseases. Objective: This study was designed to discover the possible role of prolactin in autoimmune blistering skin diseases. The main goal was to compare the serum prolactin levels and the frequency of hyperprolactinemia in autoimmune skin...
متن کاملAutoantibodies against adhesion molecules and structures in blistering skin diseases
E ven by clinical and histologic findings alone it is reasonable to suspect that the pathogenesis of certain blistering skin diseases might involve abnormalities in adhesion structures. The best defined buUous diseases in this regard are pemphigus (of which there are two basic types: vulgaris and foliaceus) and bullous pemphigoid (BP) (1-3). Histology shows that the blisters in pemphigus result...
متن کاملA bridge between chemistry and biology.
Chemical biology is an interdisciplinary field that is undergoing rapid expansion around the globe. Recently, the Japanese Society for Chemical Biology sponsored its inaugural scientific meeting to discuss research at the interface of chemistry and biology.
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ژورنال
عنوان ژورنال: Histopathology
سال: 2010
ISSN: 0309-0167,1365-2559
DOI: 10.1111/j.1365-2559.2009.03442.x